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What does phentermine and Topamax do together?

Author

Matthew Cannon

Updated on February 27, 2026

What does phentermine and Topamax do together?

Combining phentermine/topiramate with a reduced-calorie diet results in greater weight loss than combining reduced calories and increased activity.

Then, why is topiramate used with phentermine?

Phentermine and topiramate combination is used together with a reduced-calorie diet and proper exercise to help you lose weight. It is also used in overweight people who may also have diabetes, high blood pressure, high cholesterol, or heart disease.

Subsequently, question is, how do you lose weight with phentermine and topiramate? For weight loss:

  1. Adults—At first, one tablet of 3.75 milligrams (mg) of phentermine and 23 mg of topiramate once a day for 14 days. After 14 days, your doctor may increase your dose to 7.5 mg of phentermine and 46 mg of topiramate once a day.
  2. Children—Use is not recommended.

Secondly, how much weight can you lose on Phentermine and Topamax?

Results from the trials showed that after 1 year of treatment with the recommended dose (7.5 mg phentermine, 46 mg topiramate), patients experienced an average weight loss of 6.7%, and those who were treated with the highest daily dose (15 mg phentermine, 92 mg topiramate) had an average weight loss of 8.9%.

How does phentermine and topiramate work together?

Phentermine is in a class of medications called anorectics. It works by decreasing appetite. Topiramate is in a class of medications called anticonvulsants. It works by decreasing appetite and by causing feelings of fullness to last longer after eating.

Should I take Topamax at night or in the morning?

At the start of treatment TOPAMAX may be taken once a day, preferably at night. After the dose is increased, it is taken twice a day. You should continue taking TOPAMAX until your doctor tells you to stop.

Do you gain weight back after stopping Topamax?

Conclusions: Loss of body weight is a reversible effect, which at 6 months after TPM discontinuation shows a clear trend to return to baseline values. HOMA-IR is the only predictive factor of weight regain.

Why is low carb bad while taking Topamax?

Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children). Avoid the use of a ketogenic or "ketosis" diet (high in fat, low in carbohydrates) while you are taking topiramate. Topiramate may cause blurred vision or impair your thinking or reactions.

What is the strongest weight loss prescription pill?

Phentermine-Topiramate extended release (Qsymia) is the most effective weight loss drug available to date. It combines an adrenergic agonist with a neurostabilizer. Daily doses with four strengths start at 3.75/23mg to 15mg/92mg. Adults with migraines and obesity are good candidates for this weight loss medication.

How much weight will you lose on Topamax?

The mean dose of topiramate was 195 mg/day (range, 100–375 mg/day). All patients lost a substantial amount of weight on topiramate. The average weight loss was 22 lb (10 kg; range, 8–56 lb [4–25 kg]).

Why do you lose weight on Topamax?

Topamax causes weight loss because it affects the appetite. People who take it and have a reduced appetite may feel hungry less often and eat less because of this. Studies have shown that Topamax may also speed up metabolism, which means that the body burns calories more quickly.

What happens if you take 2 phentermine in one day?

An overdose of phentermine can be fatal.

Overdose symptoms may include confusion, panic, hallucinations, extreme restlessness, nausea, vomiting, diarrhea, stomach cramps, feeling tired or depressed, irregular heartbeats, weak pulse, seizure, or slow breathing (breathing may stop).

Is topiramate 50mg used for weight loss?

Off-Label Use for Weight Loss, Psychiatric Disorders

Topamax is also used to control binging and purging, and to promote weight loss. However, this is not an FDA-approved use.

Can I lose 20 pounds in a month on phentermine?

Several clinical studies have proven that phentermine can boost fat loss. The expected average weight loss with phentermine use is 5% of your initial body weight. Yet, over 12 weeks, it can be as high as 10%. This equates to a weight loss of 10–20 pounds (4.5–9 kg) for a 200 pound (90.7 kg) person ( 8 ).

Can phentermine be prescribed via telemedicine?

**Complimentary within 30 days of telehealth appointment, in-office only. You may choose how to receive your Phentermine! Either have your prescription phoned into your local pharmacy at your cost, OR have it shipped to your home by 2-3 day tracked delivery for an additional $20 (includes prescription cost).

What should you not take with phentermine?

Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

Does phentermine/topiramate cause hair loss?

Weight loss medications like phentermine can cause hair loss, but the side effect isn't often listed. This is because dieters who lose their hair are often also nutrient-deficient or may have underlying health conditions contributing to their hair loss.

Can you take Topamax to lose weight?

Topamax for weight loss

Topamax isn't approved for weight loss. However, the drug may reduce your appetite, which may lead you to lose weight. In clinical studies, weight loss occurred in 6% to 17% of people who took Topamax.

Can I take my vitamins with phentermine?

Phentermine may interact with other medications. Phentermine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

Is phentermine a narcotic?

Phentermine: an appetite-suppressant amphetamine classified as a narcotic in France.

Can you take phentermine every other day and still lose weight?

We suggest for those women trying to lose 25 lbs or less, you start weaning off the phentermine after the second month. Take the pill every other day for two weeks, then every third day, until you are down to 1 pill a week (usually Sunday) then stop completely.

Does phentermine insomnia go away?

Insomnia: Because it is a stimulant, phentermine will most likely keep you awake if you take it too late in the day. This side effect also decreases in most patients after they have been on the medication for several weeks.

How long does it take for phentermine to kick in?

Phentermine is absorbed through the gastrointestinal tract and reaches peak concentrations in the blood in three to 4.4 hours, by which time you should start feeling the effects, alerting you that the drug is working. The short-term effects of Adipex may include: Decreased appetite.

What are the side effects of phentermine and topiramate?

Dizziness, drowsiness, dry mouth, difficulty sleeping, tiredness, tingling of the hands/feet, constipation, and metallic taste may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

How long do you stay on Topamax for migraines?

For migraines, it can take 1 month for migraine attacks to be less frequent. But it can take 2 to 3 months for topiramate to fully work. How long will I take it for? Once your condition is under control, you'll usually need to keep taking topiramate for many years.

Does topiramate contain phentermine?

Qsymia contains phentermine hydrochloride, a sympathomimetic amine anorectic, and topiramate, a sulfamate-substituted monosaccharide related to fructose antiepileptic drug.

What does phentermine 37.5 mg do?

Phentermine is a medication used to aid with weight loss. It works by activating your sympathetic (“fight or flight”) nervous system, so it's called a “sympathomimetic” drug or “stimulant.” Activating your sympathetic nervous system decreases your appetite, and people who take phentermine tend to eat less.

What medications interfere with phentermine?

Severe interactions of phentermine include:
  • iobenguane i 123.
  • isocarboxazid.
  • linezolid.
  • phenelzine.
  • procarbazine.
  • selegiline transdermal.
  • tranylcypromine.

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